We are interested in the crosstalk of coagulation and inflammation and our research broadly addresses open questions related to coagulation protease signaling networks in the integration and modulation of inflammatory stimuli in immune cells. We are interested in translational research that deciphers molecular mechanisms of diseases in infection, cardiovascular disease and aging and evaluates clinically relevant interventional proof-of-principle molecular probes in disease models. We are applying single cell sequencing approaches of immune cells from genetically modified mice and disease models and are interested in data integration from model organism to human patient cohorts.

Positions held

Since 2015 
Principle Investigator, German Center for Cardiovascular Research (DZHK)

Since 2014 
Scientific Director, Center for Thrombosis and Hemostasis, Mainz, Germany

Since 2013 
Alexander von Humboldt Professor, Johannes Gutenberg University Mainz, Germany

Since 2005 
Professor, Scripps Research, La Jolla, CA, USA

1992-2005 
Assistant Associate Professor (tenured 2001), The Scripps Research Institute, La Jolla, CA, USA

1990-1992 
Senior Research Associate, The Scripps Research Institute, La Jolla, CA, USA

1988-1990 
German Research Foundation Research Fellowship, Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA, USA

1987-1988 
Research Associate, Clinical Research Unit for Blood Coagulation and Thrombosis of the Max-Planck Gesellschaft

Education

1986-1987 
Training in Transfusion Medicine, German Army Blood Bank, Koblenz, Germany

1984-1986 
Doctoral Fellowship, Clinical Research Unit for Blood Coagulation and Thrombosis of the Max-Planck Gesellschaft, M.D.

1977-1984 
Medical Studies, Justus Liebig University Giessen, Germany