"Under the Hood" Seminar with

Dr. Federico Marini, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University Mainz

In an era where omics data generation became a standard tool to answer biological and medical research hypotheses throughout many application scenarios, the analysis and interpretation could be considered the next bottleneck to unlock its full potential.
I will present some ideas and tools that aim to solve this problem, by combining interactivity and reproducibility of the performed analyses, showcasing our R/Bioconductor packages iSEE and GeneTonic for efficient exploration and integration of omics data (including examples with bulk and single-cell RNA-seq).

IQCB Seminar with

Dr. Oscar Palomino Hernandez, Department of Chemistry, Johannes Gutenberg University Mainz

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"Under the Hood" Seminar with

Dr. Laurence Ettwiller, New England Biolabs, USA

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We are thrilled to announce the Nanopore Hackathon on "Democratising RNA Modification Detection" which will bring together innovators, developers, and researchers from diverse backgrounds to collaboratively tackle challenges in RNA modification detection using the groundbreaking technologies of Nanopore Sequencing and Machine Learning!

The event is organised in collaboration with the group of IQCB board member Susanne Gerber from the University Medical Center Mainz, Mark Helm from the Johannes Gutenberg University Mainz, Andre Holzer and our collaborators at Oxford Nanopore Technologies.

Register here until 31.08.2024

Our Hackathon Event is fully booked!

“Under the Hood” Seminar with

Prof. Dr. Rodrigo Mora, University of Costa Rica

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“Under the Hood” Seminar with

Dr. Erika E. Rodriguez-Torres, Autonomous University of Hidalgo, Pachuca de Soto, Hidalgo, Mexico

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Join us at BioZentrum I or online

The registration link and agenda have been sent to all group leaders.

Joint Seminar of RMaP & IQCB with

Jun.-Prof. Dr. Redmond Smyth, Helmholtz Institute for RNA-based Infection Research (HIRI)

Join us at BioZentrum I or online

About RMaP

Join us at BioZentrum I or online

“Under the Hood” Seminar with

Prof. Dr. Sara Vieira-Silva, Institute of Medical Microbiology & Hygiene, University Medical Center Mainz and Institute of Molecular Biology (IMB) Mainz

The gut microbiota is a key actor in human health, with roles ranging from nutritional complementing, immune modulation and pathogen exclusion. The dissection of the gut microbiota using metagenomics has linked faecal microbial community diversity, composition, and functional potential to a wide range of diseases, and to ageing trajectories. However, in order to work towards therapeutic modulation of the microbiota, its is essential to go beyond biomarker identification and quantify interactions between the microbiome and suboptimal health. Here, we will show that the adoption of quantitative methods for microbiome profiling helps us understand the microbiota variation within the boundaries of health, and therefore refine a definition of microbiome deviations with impact on health (dysbiosis). This in turn allows the quantification of the contribution of dysbiosis to disease progression by exploiting clinical cohorts. Finally, we use this quantitative approach to analyse the impact of a dietary intervention with the aim of refining strategies for modulation of the microbiota to promote health.

The IQCB seminar series “Under the Hood” provides a forum for scientists at all career levels to present the technical side of their research. Talks are aimed at an audience interested in the methods, algorithms, and programs used to address a specific research question. “Under the Hood” talks stimulate lively discussions among researchers facing similar computational challenges in their research, lead to transfer of technical knowledge and ideas and promote collaboration.

“Under the Hood” Seminar with

Jun.-Prof. Dr. Janina Hesse, Research Group Leader from the Leibniz Institute for Resilience Research Mainz

Neurons have traditionally been classified into two types depending on their frequency-input curve. Both types are associated with a particular dynamic transition from rest to spiking. Our work highlights a third transition, for which we found experimental evidence in hippocampal slices. For typical Hodgkin-Huxley-like neuron model, we present a universal bifurcation structure, with the separation of time-scale between voltage and ion channel dynamics as one of the bifurcation parameters. We predict that the strongest changes in synchronization with small parameter changes occur at a particular co-dimension two bifurcation (saddle-node loop bifurcation), and we present characteristics of this transition, from changes in firing rate to phase response curve and synchronization.

The IQCB seminar series “Under the Hood” provides a forum for scientists at all career levels to present the technical side of their research. Talks are aimed at an audience interested in the methods, algorithms, and programs used to address a specific research question. “Under the Hood” talks stimulate lively discussions among researchers facing similar computational challenges in their research, lead to transfer of technical knowledge and ideas and promote collaboration.

IQCB Seminar with

Prof. Daniel Franks from the Department of Biology, University of York, UK

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“Under the Hood” Seminar with

Dr. Juha Karjalainen from the Institute for Molecular Medicine Finland and Broad Institute of MIT and Harvard

I’ll present the FinnGen public-private partnership project that has enabled us to discover previously unknown genetics from the analysis of 500,000 individuals. The presentation will cover the project setup, the health registries and data, research results, computational aspects, and the larger context of global biobank genetics research.

The IQCB seminar series “Under the Hood” provides a forum for scientists at all career levels to present the technical side of their research. Talks are aimed at an audience interested in the methods, algorithms, and programs used to address a specific research question. “Under the Hood” talks stimulate lively discussions among researchers facing similar computational challenges in their research, lead to transfer of technical knowledge and ideas and promote collaboration.

Link to Agenda

IMB-IQCB Seminar with Dr. Heiko Runz from the Heidelberg/Mannheim Health + Life Science Alliance, EMBL Heidelberg.

The seminar is hosted by Prof. Dr. Christof Niehrs and Prof. Dr. Peter Baumann.

Please register here https://forms.office.com/e/DfFiB4zWRm. Registration will close on 16th January at 9 AM.

Link to Program

The IQCB seminar series “Under the Hood” provides a forum for scientists at all career levels to present the technical side of their research. Talks are aimed at an audience interested in the methods, algorithms, and programs used to address a specific research question. “Under the Hood” talks stimulate lively discussions among researchers facing similar computational challenges in their research, lead to transfer of technical knowledge and ideas and promote collaboration.

“Under the Hood” Seminar with

Dr. Hristo Todorov from the Institute of Human Genetics, University Medical Center Mainz